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Target intelligence / Profile preview
Frizzled homolog 10 (FZD10)
- Target
- FZD10
- Molecular classification
- Receptor, Seven-pass transmembrane glycoprotein receptor, Frizzled receptor
01
Overview
FZD10 is a receptor for Wnt proteins, primarily functioning in the canonical Wnt/β-catenin signaling pathway. Upon ligand binding, it forms complexes with co-receptors like LRP5/6, stabilizing β-catenin and regulating gene transcription involved in cell proliferation, differentiation, migration, and development. It is expressed in various tissues during embryogenesis and adulthood, and its upregulation has been observed in certain cancers, including colon cancer and synovial sarcomas.
- Other names
- Frizzled Class Receptor 10Fz-10CD350HFz10FzE7Seven Transmembrane Spanning Receptor[8][2]
02
Mechanism of action
Wnt ligand binding prevents β-catenin degradation leading to nuclear translocation and target gene activation.
03
Biological functions
Signal transductionCell proliferationCell differentiationCell migrationDevelopmental processesWnt signaling pathway regulationCanonical Wnt/β-catenin signalingNon-canonical Wnt signaling
04
Disease associations
CancerColon cancerSynovial sarcomaDeafnessAutosomal dominant disorders
05
Safety considerations
Aberrant activation of the canonical Wnt pathway can lead to tumorigenesis.Potential off-target effects due to sequence homology with other frizzled family members.
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