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Frizzled receptor

Molecular classification: G protein-coupled receptor, Receptor

Overview

Frizzled receptors are a family of atypical G protein-coupled receptors (GPCRs) that primarily function as the main receptors for Wnt proteins, mediating key signaling pathways involved in embryonic development, cell polarity, stem cell biology, and tissue regeneration. They are found across a wide range of species. They are considered promising therapeutic targets due to their central role in development and disease, including cancer.

Mechanism of action

Wnt signaling modulation; varies depending on the specific drug and Frizzled receptor subtype.

Biological functions

Signal transductionCell proliferationCell polarityEmbryonic patterningMorphogenesisNeural synapse formationStem cell maintenanceStem cell differentiationTissue regeneration

Disease associations

CancerDevelopmental defectsFamilial exudative vitreoretinopathy

Safety considerations

Potential for developmental defects if Wnt signaling is disrupted during embryogenesis.Aberrant activation can lead to tumorigenesis.

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