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Target intelligence / Profile preview
Frizzled Receptor 2 (FZD2)
- Target
- FZD2
- Molecular classification
- Atypical G protein-coupled receptor, Seven-transmembrane receptor
01
Overview
Frizzled Receptor 2 (FZD2) is a seven-transmembrane domain receptor belonging to the Frizzled family. It functions as a receptor for Wnt signaling proteins and plays a critical role in cell proliferation, cell polarity, embryonic development, and neural synapse formation. Aberrant FZD2 activation is implicated in various diseases, including cancer, where it acts as an oncogene, and neurodegenerative diseases like ALS. It also serves as a receptor for Clostridioides difficile toxin B (TcdB).
- Other names
- Frizzled-2
02
Mechanism of action
Wnt signaling pathway modulation
03
Biological functions
Cell proliferationCell polarityEmbryonic developmentNeural synapse formationSignal transduction
04
Disease associations
CancerNeurodegenerative diseaseInfectious disease
05
Safety considerations
Potential for off-target effects due to the broad role of Wnt signaling in development and tissue homeostasis.
06
Biomarkers
FZD2 expression level (prognostic biomarker in cancer)
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