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Frizzled receptor 5 (FZD5)
- Target
- FZD5
- Molecular classification
- G protein-coupled receptor (GPCR), Class F GPCR, Seven-transmembrane receptor, Frizzled receptor
01
Overview
Frizzled receptor 5 (FZD5) is a member of the Frizzled family of G protein-coupled receptors that serve as receptors for Wnt signaling proteins. FZD5 plays a crucial role in embryonic development, stem cell regulation, neuronal development, and angiogenesis. It activates both canonical (β-catenin-dependent) and non-canonical (planar cell polarity, calcium, JNK) signaling pathways. FZD5 is overexpressed in several cancers, contributing to tumorigenesis and cancer progression.
- Other names
- Frizzled-5Fz-5Fzd-5hFz5
02
Mechanism of action
Wnt signaling modulation
03
Biological functions
Signal transductionEmbryonic developmentStem cell regulationNeuronal polarizationAngiogenesisWnt signaling
04
Disease associations
CancerPancreatic cancerOvarian cancerGastric cancerColorectal cancerBreast cancer
05
Safety considerations
Potential for off-target effects due to involvement in multiple developmental pathways
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