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Target intelligence / Profile preview
Frizzled Receptor 7 (FZD7)
- Target
- FZD7
- Molecular classification
- G protein-coupled receptor, Receptor, Frizzled receptor
01
Overview
Frizzled receptor 7 (FZD7) is a seven-transmembrane domain protein that functions as a receptor for Wnt signaling proteins. It mediates canonical Wnt/β-catenin signaling and is involved in cell proliferation, differentiation, and migration. FZD7 plays essential roles in embryonic development and stem cell regulation. Overexpression or dysregulation of FZD7 has been linked to various cancers, particularly those affecting the gastrointestinal tract, promoting tumor proliferation, progression, invasion, and metastasis.
02
Mechanism of action
Small molecule inhibitors targeting transmembrane domain to block canonical signaling and inhibit Wnt/β-catenin pathway activation.
03
Biological functions
Signal transductionCell proliferationCell differentiationCell migrationStem cell regulationWnt signaling pathway activation
04
Disease associations
Cancer
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