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Frizzled Receptor 8 (FZD8)
- Target
- FZD8
- Molecular classification
- G protein-coupled receptor, Receptor, Class Frizzled GPCRs
01
Overview
Frizzled receptor 8 (FZD8) is a seven-transmembrane domain protein and a member of the frizzled gene family, acting as a receptor for Wnt signaling proteins. It participates in canonical (beta-catenin dependent) and non-canonical Wnt signaling pathways, influencing cell proliferation, embryonic development, and tissue homeostasis. Dysregulation of FZD8 is implicated in several cancers, making it a potential therapeutic target.
- Other names
- Frizzled family receptor 8Fz-8Fz8
02
Mechanism of action
Wnt signaling modulation
03
Biological functions
Signal transductionCell proliferationEmbryonic developmentMaintenance of tissue homeostasisRegulation of stem cellsCell polarityCell migration
04
Disease associations
CancerGastric CancerRenal Cell CarcinomaTriple-negative Breast Cancer
05
Safety considerations
Potential for off-target effects due to widespread Wnt signaling involvementTumorigenesis or cancer progression
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