Frizzled receptor and Low-density lipoprotein receptor-related protein 5 or 6 (FZD and LRP5 or LRP6)

The Frizzled/LRP5/6 receptors form a membrane receptor complex critical for *canonical Wnt/β-catenin signaling*[4]. Upon binding Secreted Wnt glycoproteins, the **seven-pass transmembrane Frizzled receptor** and the **single-pass LRP5 or LRP6 co-receptor** recruit cytoplasmic partners (Dishevelled, Axin), leading to inhibition of β-catenin degradation and transcriptional activation of Wnt target genes[1][2][4][5]. These proteins regulate vital processes including cell fate, proliferation, differentiation, embryonic development, and stem cell maintenance. Dysfunction or hyperactivation is linked to numerous diseases, such as **cancer**, **bone disorders**, and **cardiovascular and metabolic conditions**. Pharmacologic targeting (antagonists, monoclonal antibodies, and pathway modulators) offers promising intervention points but requires caution due to widespread roles in tissue homeostasis and regeneration[1][4][8].

Other names

Fz (Frizzled)FZDLRP5LRP6Wnt receptor complex

Inhibition (antagonists such as sclerostin or DKK1 block LRP5/6, suppressing Wnt signaling)\nActivation (agonists enhance Wnt/β-catenin signaling through co-receptor stabilization)\nCompetitive blockade (competing for Wnt binding or interrupting FZD–LRP5/6 interaction)\nDownstream modulation of β-catenin stability in cytoplasm/nucleus