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Target intelligence / Profile preview
Fructose-1,6-bisphosphatase isozyme 2 (None)
- Target
- None
- Molecular classification
- Enzyme, Hydrolase
01
Overview
Fructose-1,6-bisphosphatase isozyme 2 (FBP2) is an enzyme that plays a key role in gluconeogenesis by catalyzing the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. It is highly expressed in muscle tissue and participates mainly in gluconeogenesis and the regulation of glycolysis/gluconeogenesis balance. Recent research has shown that loss or downregulation of FBP2 contributes to cancer cell metabolic reprogramming and may represent a therapeutic target for certain tumors such as soft tissue sarcomas.
- Other names
- Fructose-bisphosphatase IIMuscle-type fructose bisphosphataseCORLK
02
Mechanism of action
Inhibits sarcoma cell proliferation through antagonism of glycolysis and restraint of mitochondrial biogenesis and respiration.
03
Biological functions
GluconeogenesisRegulation of glycolysis/gluconeogenesis balanceModulation of serine metabolism and TCA cycle intermediatesRegulation of mitochondrial biogenesisRegulation of respiration
04
Disease associations
Cancer
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