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Target intelligence / Profile preview
Fructose-1,6-bisphosphatase 1 (FBP1)
- Target
- FBP1
- Molecular classification
- Enzyme, Phosphatase
01
Overview
Fructose-1,6-bisphosphatase 1 (FBP1) is a key regulatory enzyme in gluconeogenesis, catalyzing the hydrolysis of fructose-1,6-bisphosphate to fructose 6-phosphate. It is a major control point in glucose production and a drug target for type II diabetes.
- Other names
- FBPaseD-fructose-1,6-bisphosphate 1-phosphohydrolase
02
Mechanism of action
Inhibition of gluconeogenesis
03
Biological functions
GluconeogenesisCalvin cycle (in plants)Regulation of blood glucose levels
04
Disease associations
Type II DiabetesHypoglycemia
05
Safety considerations
Hypoglycemia (with excessive inhibition)
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