Fructose-bisphosphatase 2 pseudogene 1 (FBP2P1)

"Fructose-bisphosphatase 2 pseudogene 1" (**FBP2P1**) is a pseudogene defined in the human genome (e.g., NCBI Gene: 100420269, Ensembl: ENSG00000290881, located on chromosome 9) and does **not code for a functional protein**[7]. As a pseudogene, it is a non-coding genetic element evolutionarily related to the functional FBP2 gene, which encodes the enzyme fructose-1,6-bisphosphatase isozyme 2 (FBP2), an important gluconeogenic regulatory enzyme[2][3]. Pseudogenes like FBP2P1 do not possess enzymatic activity, are not drug targets, and do not have roles in canonical biological pathways or disease. Any disease associations or druggability pertain to the **functional FBP2 enzyme** and not its pseudogene FBP2P1[2][3][7]. **Key distinctions:** - The **FBP2** gene encodes a functional gluconeogenic enzyme with some clinical relevance[2][3]. - The **FBP2P1 pseudogene** lacks protein-coding potential and has no current or likely future therapeutic relevance[7]. **Summary:** "FBP2P1" is not a therapeutic target and represents a pseudogene, making it ineligible for fields such as molecular classification, biological function, druggability, disease associations, etc. There is nothing to suggest it carries any clinical, molecular, or pharmacological relevance; any confusion likely results from conflation with the true FBP2 gene[7][2][3].