Fructose-bisphosphate aldolase B (Aldolase B)

Fructose-bisphosphate aldolase B (Aldolase B) is a Class I enzyme that catalyzes the reversible cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, a key step in both glycolysis and gluconeogenesis[1][2][5][6]. It is one of three isoenzymes in mammals, predominantly expressed in liver, kidney, and small intestine, and uniquely able to catalyze the cleavage of fructose 1-phosphate as well as fructose 1,6-bisphosphate[1][6]. Mutations in the *ALDOB* gene cause hereditary fructose intolerance, a metabolic disease characterized by hypoglycemia and liver dysfunction following fructose ingestion[1]. Aldolase B has also been implicated in cancer biology as a suppressor of oxidative pentose phosphate pathway activity by stabilizing the G6PD and TP53 complex[2]. No approved drugs specifically target this enzyme, but it may become more relevant as a biomarker or metabolic target in specific clinical scenarios.

Other names

Liver-type aldolaseALDOBEC 4.1.2.13Fructose-1,6-bisphosphate aldolase B

Catalytic inhibition (small molecule inhibitors might act by reversibly inhibiting enzyme activity, studied primarily in research setting)