Fructose-bisphosphate aldolase C (ALDOC)

Fructose-bisphosphate aldolase C (ALDOC) is a class I glycolytic enzyme predominantly expressed in the brain (notably hippocampus and Purkinje cells), but also found in smooth muscle and neuronal tissues[1][5]. It catalyzes the reversible conversion of fructose-1,6-bisphosphate (and fructose-1-phosphate) into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate—a key step in glycolysis and gluconeogenesis[1][2][4]. Alongside essential roles in energy metabolism and ATP production, ALDOC may also have diverse "moonlighting" functions, including roles in cellular stress response and cytoskeletal regulation[1][7]. Aberrant expression of ALDOC is implicated in various cancers and may serve as a biomarker for certain diseases[4][5]. While specific clinical drugs do not yet target ALDOC, the enzyme is under investigation as an anti-cancer target and as a vaccine antigen for infectious diseases due to its role in pathogen metabolism and immune responses[7].

Other names

Aldolase CALDOCALDCBrain-type aldolaseFructoaldolase CAldolase 3Fructose-1,6-biphosphate triosephosphate lyaseEpididymis secretory sperm binding protein

Inhibition of glycolytic activity (reducing ATP and anabolic precursors in rapidly proliferating cells, e.g., cancer)[7]. Vaccine antigen (eliciting immune response against pathogens expressing aldolase orthologs)[7].