Fucose-1-phosphate guanylyltransferase–troponin I-interacting kinase fusion protein (FPGT-TNNI3K)

The “FPGT-TNNI3K readthrough” describes a *putative fusion protein* that is theoretically produced from a conjoined transcript spanning the neighboring *FPGT* and *TNNI3K* genes, resulting in a fusion protein with potential functional domains from both parental proteins (FPGT and the cardiac kinase TNNI3K). However, there is no strong evidence that this fusion is naturally expressed at meaningful levels in human tissue. Large datasets including the GTEx project do not report its protein product, and it is not recognized in standard protein databases such as UniProt as a canonical entity[1][5]. The protein may be detected at the transcript level at low frequency, but remains uncharacterized at the functional or clinical level. *FPGT* alone is an enzyme in the fucosylation pathway and implicated in glycoprotein and glycolipid synthesis. *TNNI3K* alone encodes a cardiac-specific kinase implicated in cardiac hypertrophy, remodeling, arrhythmias, and conduction disease, with evidence suggesting both protective and detrimental roles in heart function, depending on the context[1][2][4]. *TNNI3K* is under investigation as a therapeutic target for heart failure and arrhythmias but is not typically referenced as a receptor or transporter[1]. **Summary of correctness:** - There is **no strong evidence** that FPGT-TNNI3K fusion is a naturally occurring or targetable molecule, nor is it a recognized receptor, enzyme, or therapeutic target. The term refers to a *theorized* fusion gene/protein with no proven expression or clinical significance[1][5]. Thus, this entry is **incorrect** as a distinct biomedical target. **Notes:** - All functional and disease-related information in literature refers to *TNNI3K*, not to the FPGT-TNNI3K readthrough or fusion protein [1][2][3][4]. - For structured data, **FPGT-TNNI3K** should generally be treated as non-canonical or annotated as a read-through/fusion, not as a real, actionable therapeutic target. If you seek information about the validated kinase *TNNI3K* (troponin I-interacting kinase), a substantial amount of disease, function, and druggability data is available[1][2][3][4]. For the FPGT-TNNI3K fusion, these data do **not** apply.

Other names

CARKTNNI3KFPGT-TNNI3K fusion proteinCardiac ankyrin repeat kinaseCardiac troponin I-interacting kinaseSerine/threonine-protein kinase TNNI3KTNNI3-interacting kinaseFPGT-TNNI3K