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Fucosyl-GM1 (FucGM1)
- Target
- FucGM1
- Molecular classification
- Glycosphingolipid, Ganglioside, Tumor-associated antigen
01
Overview
Fucosyl-GM1 is a glycosphingolipid, specifically a monosialylated ganglioside with an α1,2-fucosylated galactose. It exhibits minimal expression in most healthy tissues but is highly prevalent in certain tumors, especially small cell lung cancer (SCLC), making it a tumor marker and an immunotherapy target. It can also be targeted by autoantibodies in autoimmune neuropathies.
- Other names
- Ganglioside FG1Fuc-GM1afucosylated ganglioside GM1
02
Mechanism of action
Antibody-dependent cellular cytotoxicity (ADCC)
03
Biological functions
Cell surface signalingCell-cell interactionTumor antigen presentation
04
Disease associations
CancerAutoimmune neuropathy
05
Safety considerations
Potential for off-target effects in sensory nervous tissueImmunogenicity of therapeutic antibodies
06
Interacting drugs
BMS-986012
07
Biomarkers
SCLC diagnosisSCLC prognosis
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