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Target intelligence / Profile preview
Fucosyl GM1 Ganglioside (FucGM1)
- Target
- FucGM1
- Molecular classification
- Glycosphingolipid, Ganglioside, Tumor-associated antigen
01
Overview
Fucosyl GM1 ganglioside (FucGM1) is a glycosphingolipid selectively expressed in tumor tissues like SCLC and some NSCLC. It plays a role in cell communication, adhesion, and signaling. FucGM1 serves as both a tumor marker for diagnostic purposes and a target for antibody-based therapies.
- Other names
- Fuc-GM1fucosyl-GM1aFuc-GM1 antigenGanglioside FG1Fuc‑GM₁fucosyl‑GМ₁aGanglioside FG₁
02
Mechanism of action
Antibody-based therapy targeting FucGM1
03
Biological functions
Cell-to-cell communicationCellular differentiationSignal transductionCell adhesion
04
Disease associations
CancerSmall Cell Lung Cancer (SCLC)Non-Small Cell Lung Cancer (NSCLC)Autoimmune neuropathies
05
Safety considerations
Potential for off-target effects due to limited expression in normal tissuesRisk of autoimmune reactionsOn-target, off-tumor toxicity
06
Interacting drugs
BMS‑986012
07
Biomarkers
FucGM1 expression in tumor tissueAntibody response to FucGM1 (in autoimmune neuropathies)
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