Fucosyl-monosialoganglioside-1 (FucGM1)

Fucosyl-monosialoganglioside-1 (Fucosyl-GM1, FucGM1) is a ganglioside consisting of a GM1 backbone with an α1,2-linked fucose moiety. It is selectively and highly expressed on the surface of small cell lung cancer cells and has sparse expression in most normal tissues, with the exception of some neurons. This molecular pattern makes FucGM1 a promising target for antibody-based immunotherapy, such as the monoclonal antibody BMS-986012, which acts by inducing immune-mediated cell death of FucGM1-positive tumor cells through mechanisms like ADCC and CDC. FucGM1 is also implicated as a biologically active membrane component distinct from the prototypical GM1 ganglioside, participating in neural differentiation and tumor cell biology via unique membrane signaling platforms. Its limited presence in healthy adult tissues, apart from some neural cells, underpins ongoing investigations for its use as both a therapeutic target and a cancer-selective biomarker.

Other names

Fucosyl-GM1FucGM1α1,2-fucosyl GM1Fuc-GM1Fuc(Gal)-GM1

Antibody-dependent cellular cytotoxicity (ADCC), Complement-dependent cytotoxicity (CDC), Antibody-dependent cellular phagocytosis (ADCP)