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Fucosylated Protein Biosynthesis

Molecular classification: Glycosylation Pathway, Metabolic Pathway

Overview

Fucosylated protein biosynthesis refers to the cellular processes by which fucose is incorporated into glycoproteins. This modification affects protein folding, stability, cell signaling, immune recognition, and development. The process involves de novo and salvage pathways for GDP-fucose synthesis, fucosyltransferases (FUTs) and protein O-fucosyltransferases (POFUTs) that catalyze fucose transfer, and nucleotide sugar transporters like SLC35C1. Aberrant fucosylation is implicated in various diseases, including congenital disorders of glycosylation and cancer.

Biological functions

Protein foldingProtein stabilityCell signalingImmune responseEmbryonic developmentCell-cell adhesion

Disease associations

Congenital disorders of glycosylationImmunodeficienciesDevelopmental abnormalitiesCancer progressionMetastasis

Safety considerations

Defects in fucosylation can lead to severe congenital disorders

Biomarkers

Fucosylation patterns in cancer

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