Target intelligence / Profile preview

Fucosyltransferase (None)

Target: None
Molecular classification: Enzyme, Transferase, Glycosyltransferase, Hexosyl-transferase

Overview

Fucosyltransferases are a family of enzymes that catalyze the transfer of an L-fucose sugar from a GDP-fucose donor to various acceptor substrates. These enzymes play critical roles in the synthesis of blood group antigens, cell adhesion, and signaling. Altered expression or function is associated with inflammation and various cancers.

Mechanism of action

Inhibition of fucosyltransferase activity (under investigation)

Biological functions

Blood group antigen synthesisCell adhesionCell signalingGlycosylation

Disease associations

CancerInflammationBlood group incompatibility

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