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Fucosyltransferase VI (FUT6)
- Target
- FUT6
- Molecular classification
- Enzyme, Glycosyltransferase, Glycosyltransferase family 10 (CAZY GT_10)
01
Overview
Fucosyltransferase VI (FUT6) is an enzyme that catalyzes the transfer of fucose from GDP-fucose to specific acceptor molecules on glycoproteins and glycolipids. It is essential for the biosynthesis of selectin ligands such as sialyl-Lewis X (sLe^x), which mediate leukocyte rolling and homing during inflammation. Ex vivo treatment of therapeutic cells with FUT6 can enhance their surface expression of sLe^x, improving their ability to interact with selectins and potentially increasing homing efficiency.
- Other names
- Alpha-(1,3)-fucosyltransferase VIFucT-VI
02
Mechanism of action
Catalyzes the transfer of fucose from GDP-fucose to N-acetylglucosamine-containing oligosaccharides.
03
Biological functions
GlycosylationFucosylationSynthesis of selectin ligandsCell adhesionImmune cell trafficking
04
Disease associations
InflammationCancer (related to altered glycosylation patterns)
05
Safety considerations
Off-target fucosylation of other molecules
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