Target intelligence / Profile preview

Functional residual capacity (FRC)

Target
FRC
01

Overview

Functional residual capacity is the volume of air present in the lungs at the end of passive expiration where the opposing elastic recoil forces of the lungs and chest wall are balanced. FRC is a critical concept in respiratory physiology, representing a pulmonary equilibrium point and is the sum of expiratory reserve volume (ERV) and residual volume (RV). It is essential as a clinical measurement for assessing lung mechanics and diseases, but is not a molecule, receptor, or direct therapeutic target. In summary, "Functional residual capacity" is a physiological measurement, not a molecular or therapeutic target. Its inclusion as a target molecule/receptor is an error.

02

Disease associations

Altered FRC is a clinical indicator in restrictive lung diseaseAltered FRC is a clinical indicator in obstructive lung disease/emphysemaAltered FRC is a clinical indicator in obesityAltered FRC is a clinical indicator in pregnancy
03

Safety considerations

Reduction or increase in FRC indicating pulmonary dysfunction
04

Biomarkers

FRC measurement in pulmonary function testingFRC as a monitor for lung disease or response to therapy

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