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Fungal Allergen
- Molecular classification
- Proteins, Enzymes, Toxins, Cell wall components (e.g., glucans)
01
Overview
Fungal allergens are immunogenic molecules found in or on fungal spores and mycelial fragments that can trigger allergic reactions, particularly type I hypersensitivity (IgE-mediated) responses, in sensitized individuals. These allergens are a significant cause of respiratory allergies such as rhinitis and asthma. Diagnosis relies on the detection of specific IgE against relevant fungal extracts, and treatment options include allergen avoidance, pharmacotherapy, and immunotherapy.
02
Mechanism of action
IgE-mediated type I hypersensitivity reaction leading to mast cell degranulation and release of inflammatory mediators.
03
Biological functions
Induction of IgE-mediated hypersensitivityMast cell degranulationImmune response
04
Disease associations
Allergic rhinitisAsthmaAllergic bronchopulmonary mycosesHypersensitivity pneumonitisAtopic dermatitis
05
Safety considerations
Variability and non-standardization of natural extractsRisk of anaphylaxis during immunotherapy
06
Interacting drugs
Antihistamines
3 more in the full profile.
07
Biomarkers
Specific IgE against relevant fungal extracts
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