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Target intelligence / Profile preview
Fungal Cell Membrane Integrity (FCMI)
- Target
- FCMI
- Molecular classification
- Lipid Bilayer, Cell Membrane, Sterol Biosynthesis, Enzyme, Lipid Metabolism
01
Overview
Fungal cell membrane integrity is crucial for fungal survival and pathogenicity. It is maintained by a phospholipid bilayer rich in ergosterol, which is a key target for antifungal drugs. Disruption of membrane integrity leads to increased permeability or lysis of the fungal cell. The membrane interacts closely with the cell wall and is involved in signaling pathways regulating growth, morphogenesis, and adaptation to environmental changes. Its unique components, particularly ergosterol, allow selective targeting by drugs.
02
Mechanism of action
Inhibition of ergosterol biosynthesis, direct binding to ergosterol, disruption of membrane integrity, inhibition of lipid synthesis/modification
03
Biological functions
Selective permeabilityNutrient uptakeWaste removalProtein localizationSignal transductionOsmotic stress responseMechanical stress responseCell wall interaction
04
Disease associations
InfectionDrug resistancePathogenicity
05
Safety considerations
Potential for off-target effects due to similarities in lipid metabolism pathways with other organisms.Development of drug resistance through alterations in lipid composition.
06
Interacting drugs
Azoles
2 more in the full profile.
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