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Target intelligence / Profile preview
Fungal cytochrome P450 14-α-demethylase (CYP51 (ERG11))
- Target
- CYP51 (ERG11)
- Molecular classification
- Enzyme, Cytochrome P450 superfamily, Monooxygenase
01
Overview
Fungal cytochrome P450 14-α-demethylase is an essential enzyme in ergosterol biosynthesis, serving as the principal target for azole antifungal drugs. Its inhibition compromises fungal membrane integrity and viability. Resistance arises through gene mutations and overexpression. Cell membrane phospholipids, while critical for fungal structure and function, are a molecular class—not a direct drug target.
- Other names
- Sterol 14-α-demethylaseLanosterol 14-α-demethylaseCYP51ERG11Erg11p
02
Mechanism of action
Inhibition of ergosterol biosynthesis by binding active site heme, disruption of membrane function
03
Biological functions
Ergosterol biosynthesisCell membrane biogenesisMembrane permeability and fluidity regulation
04
Disease associations
Infection (fungal)Antifungal resistance
05
Safety considerations
Resistance due to CYP51 alterationsCYP450 inhibition in humansDrug interactions
06
Interacting drugs
Fluconazole
6 more in the full profile.
07
Biomarkers
ERG11/CYP51 expressionErgosterol contentCYP51 mutations
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