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Target intelligence / Profile preview
Fungal Cytochrome P450 Enzyme (CYP)
- Target
- CYP
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase, Heme-thiolate protein
01
Overview
Fungal cytochrome P450 enzymes (CYPs) are a large and diverse superfamily of heme-containing monooxygenases found throughout the fungal kingdom. These enzymes play essential roles in both primary and secondary metabolism, contributing to the biosynthesis of structural components, signaling molecules, detoxification of xenobiotics, and production of a wide array of secondary metabolites. Fungi possess more diverse CYP families than plants, animals, or bacteria. Many antifungal drugs target specific fungal P450 enzymes—most notably azole drugs inhibiting lanosterol 14α-demethylase (CYP51A), disrupting ergosterol synthesis essential for cell membrane integrity in fungi.
02
Mechanism of action
Inhibition of lanosterol 14α-demethylase (CYP51A) and disruption of ergosterol synthesis.
03
Biological functions
Ergosterol synthesisNatural product biosynthesisXenobiotic detoxificationSteroid metabolismBiosynthesis and modification of secondary metabolites
04
Disease associations
InfectionFungal pathogenicity
05
Safety considerations
Drug-drug interactions due to CYP inhibitionPotential for resistance development
06
Interacting drugs
Azole antifungals (e.g., Fluconazole, Itraconazole, Voriconazole)
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