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Target intelligence / Profile preview
Fungal Drug Efflux System (N/A)
- Target
- N/A
- Molecular classification
- Transporter, ABC Transporter, MFS Transporter
01
Overview
The fungal drug efflux system comprises membrane-bound transporter proteins that actively export antifungal agents and other toxic compounds out of fungal cells. This mechanism is a major contributor to multidrug resistance (MDR) in pathogenic fungi. Key protein families include ATP-binding cassette (ABC) transporters and major facilitator superfamily (MFS) transporters. Targeting these efflux pumps is a therapeutic strategy to combat antifungal resistance.
- Other names
- Fungal Efflux PumpFungal Drug Resistance TransporterFungal Multidrug Resistance (MDR) Efflux System
02
Mechanism of action
Active transport of antifungal agents out of fungal cells, reducing intracellular drug concentrations and enabling survival.
03
Biological functions
Drug effluxDetoxificationXenobiotic transportVirulence factor
04
Disease associations
InfectionAntifungal resistanceTreatment failure
05
Safety considerations
Off-target effects of efflux pump inhibitors on human homologuesSpecificity of inhibitors for fungal efflux pumpsRedundancy of efflux pumps leading to compensatory mechanisms
06
Interacting drugs
Azoles
1 more in the full profile.
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