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Fungal Lanosterol 14α-Demethylase
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Fungal lanosterol 14α-demethylase is a cytochrome P450 enzyme (CYP51) that catalyzes the removal of the 14α-methyl group from lanosterol, a crucial step in ergosterol biosynthesis. It is a primary target for azole antifungals, which inhibit its activity, leading to ergosterol depletion and fungal cell death. Resistance can develop through mutations, overexpression, or efflux pump upregulation.
- Other names
- Sterol 14α-demethylaseCYP51ERG11
02
Mechanism of action
Inhibition of lanosterol 14α-demethylase, leading to ergosterol depletion and accumulation of toxic sterol intermediates.
03
Biological functions
Sterol biosynthesisErgosterol synthesis
04
Disease associations
Infection
05
Safety considerations
Off-target effects due to conservation across eukaryotesDevelopment of drug resistanceAmino acid substitutions in the active site
06
Interacting drugs
Fluconazole
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