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Target intelligence / Profile preview
Fungal Lanosterol 14-alpha Demethylase (CYP51)
- Target
- CYP51
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Fungal lanosterol 14-alpha demethylase is a cytochrome P450 enzyme (CYP51) essential for ergosterol biosynthesis in fungi. It catalyzes the removal of the 14α-methyl group from lanosterol, a key step in ergosterol production. Ergosterol is vital for fungal cell membrane function. The enzyme is a primary target for azole antifungals. Inhibition disrupts membrane integrity, leading to fungal cell death. Resistance development and potential off-target effects are important considerations.
- Other names
- ERG11Lanosterol 14α-demethylaseSterol 14-alpha demethylase
02
Mechanism of action
Azoles bind to the heme iron of Lanosterol 14-alpha Demethylase, inhibiting its enzymatic activity and blocking ergosterol synthesis.
03
Biological functions
Steroid biosynthesisErgosterol biosynthesisCell membrane integrityCell membrane permeabilityCell membrane fluidity
04
Disease associations
InfectionFungal infections
05
Safety considerations
Resistance developmentPotential for off-target effects (similarity with human CYP51)Drug interactions
06
Interacting drugs
Fluconazole
2 more in the full profile.
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