Fungal membrane integrity

The integrity of the fungal cell membrane is a fundamental property required for survival, growth, and pathogenicity of fungi[1]. The membrane is composed primarily of a lipid bilayer containing phospholipids, ergosterol, and various proteins, which together provide a selective barrier and contribute to the regulation of cellular processes, nutrient transport, signal transduction, and interaction with the environment[2]. Disruption of membrane integrity—typically by targeting ergosterol biosynthesis, membrane proteins, or cell wall synthesis—is the main mechanism of many antifungal drugs[1][2][3]. Damage to the membrane leads to increased permeability, loss of cellular homeostasis, and ultimately fungal cell death[3]. However, as "fungal membrane integrity" is a broad functional concept and not a specific molecular entity, structured target data should reference the actual membrane components (e.g. Erg11, ergosterol, or transmembrane proteins) for precise analyses. If structured data are needed for individual membrane components (e.g. Erg11, ergosterol, GPCRs), these should be queried separately.

Other names

Cell membrane homeostasis (fungi)Fungal plasma membrane functionFungal cell membrane integrityFungal cytoplasmic membrane integrity

Disruption of membrane integrity by pore formation (Amphotericin B); Inhibition of ergosterol biosynthesis, altering membrane fluidity and permeability (Azoles, Allylamines); Inhibition of cell wall synthesis, indirectly affecting membrane homeostasis (Echinocandins, chitosan); Direct permeabilization of fungal cell membranes, causing cell death (PHMB).