Fungal metal-dependent enzymes

Fungal metal-dependent enzymes and pathways represent a broad class of essential biological processes in fungi that require metal ions, such as iron, copper, and zinc, as cofactors for enzymatic activity [NIH, mdedge.com]. These enzymes are involved in critical functions including the detoxification of reactive oxygen species (e.g., catalase and peroxidase), mitochondrial electron transport (via cytochromes), and nutrient acquisition [dokumen.pub, NIH]. The antifungal drug ciclopirox exerts its effect by chelating polyvalent cations like Fe3+ and Al3+, which deprives these enzymes of their necessary metal cofactors [mdedge.com, dokumen.pub]. This inhibition leads to the accumulation of toxic metabolites, disruption of mitochondrial function, and damage to cell membranes, ultimately resulting in fungal cell death [NIH]. Because this mechanism targets multiple enzymes and pathways simultaneously, it provides broad-spectrum activity against dermatophytes, yeasts, and molds while making the development of resistance more difficult [mdedge.com, NIH]. These pathways are key therapeutic targets in the management of superficial fungal infections such as onychomycosis and seborrheic dermatitis [NIH, mdedge.com].

Other names

Fungal metal-dependent enzymes and pathwaysMetal-dependent fungal enzymesPolyvalent cation-dependent enzymesFungal iron-dependent enzymes

Chelation of polyvalent cations (e.g., Fe3+, Al3+) leading to the inhibition of metal-dependent enzymes and disruption of fungal metabolism [NIH, mdedge.com].