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Target intelligence / Profile preview
Fungal Squalene Epoxidase (SQLE)
- Target
- SQLE
- Molecular classification
- Enzyme, Flavoprotein monooxygenase
01
Overview
Fungal squalene epoxidase (SQLE), also known as squalene monooxygenase, is a key FAD-dependent enzyme in the ergosterol biosynthesis pathway of fungi. It catalyzes the stereospecific conversion of squalene to 2,3(S)-oxidosqualene, which is essential for producing ergosterol, the principal sterol component of fungal cell membranes. SQLE is a validated antifungal drug target, and its inhibition leads to accumulation of squalene and depletion of ergosterol, disrupting membrane integrity and function. Resistance mutations have been identified, posing a challenge for antifungal development.
- Other names
- Squalene Monooxygenase
02
Mechanism of action
Noncompetitive inhibition via hydrophobic pocket binding
03
Biological functions
Ergosterol biosynthesisCatalysisLipid metabolism
04
Disease associations
Infection
05
Safety considerations
Drug resistance
06
Interacting drugs
Terbinafine
2 more in the full profile.
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