Target intelligence / Profile preview

Furin (PACE)

Target: PACE
Molecular classification: Enzyme, Serine protease, Subtilisin-like proprotein convertase (PC), Peptidase S8 family member

Overview

Furin is a calcium-dependent serine endoprotease that cleaves precursor proteins at paired basic amino acid motifs—typically at Arg-X-(Lys/Arg)-Arg↓ sites. It plays critical roles in activating hormones, growth factors, and viral glycoproteins, thereby influencing pathogen virulence. Aberrant furin activity has been linked to multiple diseases, including cancer and infectious diseases, making it an attractive target for drug development.

Other names: Paired basic amino acid cleaving enzymePCSK3Dibasic-processing enzymePaired basic amino acid residue-cleaving enzyme

Mechanism of action

Proteolytic cleavage of precursor proteins at Arg-X-(Lys/Arg)-Arg↓ sites.

Biological functions

Proteolytic processingActivation of hormonesActivation of growth factorsActivation of viral glycoproteinsSecretory granule acidification regulation

Disease associations

CancerAtherosclerosisHypercholesterolemiaInfectious diseasesJuvenile hemochromatosis

Safety considerations

Potential for off-target effects due to similarity with other proprotein convertases.Inhibition may disrupt normal physiological processes involving furin.

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