Target intelligence / Profile preview

Furin Convertase (Furin)

Target: Furin
Molecular classification: Enzyme, Serine Protease, Subtilisin-like Proprotein Convertase

Overview

Furin convertase, or Furin, is a calcium-dependent serine endoprotease that belongs to the subtilisin-like proprotein convertase family. It plays a crucial role in processing latent precursor proteins into their active forms by cleaving at paired basic amino acid sites. Furin is essential for normal hormone processing, immune tolerance, and other regulatory functions. It has also been implicated in disease processes such as cancer and vascular diseases.

Other names: PACEPaired Basic Amino Acid Cleaving Enzyme

Mechanism of action

Inhibition of Furin's proteolytic activity

Biological functions

Proteolytic processingProtein activationHormone maturationRegulation of protein traffickingImmune toleranceSecretory pathway

Disease associations

CancerCardiovascular diseaseVascular diseasesInfection

Safety considerations

Potential for off-target effects due to broad substrate specificityDisruption of normal protein processing pathways

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