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Target intelligence / Profile preview
Fusion cytosine deaminase-uracil phosphoribosyltransferase enzyme (FCU1 enzyme)
- Target
- FCU1 enzyme
- Molecular classification
- Enzyme (fusion enzyme, synthetic), Other (genetic selection tool)
01
Overview
FCU1 is a synthetic fusion enzyme combining cytosine deaminase and uracil phosphoribosyltransferase activities. It is used in genetic engineering as a selectable marker—cells expressing FCU1 convert non-toxic 5-fluorocytosine into cytotoxic 5-fluorouracil and its phosphorylated metabolites, allowing for selective cell elimination upon 5-FC treatment. This tool is widely utilized in laboratory genetic manipulations but is not a native protein in humans or other model organisms, nor is it a therapeutic target[3].
- Other names
- FCU1fusion cytosine deaminase-uracil phosphoribosyltransferase
02
Mechanism of action
Enzymatic conversion: 5-fluorocytosine → 5-fluorouracil and 5-fluorouridine-5'-monophosphate, leading to cellular toxicity
03
Biological functions
Negative selection in genetic engineeringenables selection/elimination of genetically modified cells exposed to 5-fluorocytosine
04
Disease associations
None as a natural disease mediator; used in *in vitro* and *in vivo* research or synthetic biology applications
05
Safety considerations
Not applicable in clinical therapy; potential cell toxicity in research due to 5-FC conversion to toxic metabolites
06
Interacting drugs
5-fluorocytosine
07
Biomarkers
None clinically; expression of FCU1 used as a marker in experimental settings
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