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Target intelligence / Profile preview
Fusion glycoprotein F0
- Molecular classification
- Fusion protein, Glycoprotein, Viral protein, Type I integral membrane protein
01
Overview
The fusion glycoprotein F0 is a viral surface protein responsible for mediating the entry of viruses, such as Human respiratory syncytial virus (HRSV) and Nipah virus (NiV), into host cells. It is synthesized as an inactive precursor that is subsequently cleaved into F1 and F2 subunits, forming a trimeric complex. This complex undergoes conformational changes to facilitate fusion between the viral envelope and the host cell membrane. It is a major target for neutralizing antibodies and vaccine development.
- Other names
- F proteinF0FRSV fusion proteinNiV fusion protein
02
Mechanism of action
Neutralization of fusion activity via antibody binding or inhibition of conformational change.
03
Biological functions
Viral entryMembrane fusionReceptor binding
04
Disease associations
Infection (HRSV)Infection (Nipah virus)
05
Safety considerations
Potential for antibody-dependent enhancement (ADE) of infection.
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