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Fusion Glycoprotein of Respiratory Syncytial Virus (RSV) – Prefusion Conformation (RSV F protein (Prefusion))
- Target
- RSV F protein (Prefusion)
- Molecular classification
- Viral Fusion Protein, Glycoprotein, Type I transmembrane protein
01
Overview
The fusion (F) glycoprotein is a major surface protein on the respiratory syncytial virus (RSV) and is essential for viral entry. It mediates fusion between the viral envelope and host cell membrane, releasing the viral genome. The prefusion conformation is a metastable state that is highly immunogenic and a prime target for neutralizing antibodies. It exists as a trimer composed of F1 and F2 subunits and undergoes significant structural rearrangements upon activation. Stabilization of the prefusion state is a key strategy in vaccine development to elicit stronger protective immunity against RSV.
- Other names
- RSV Fusion Protein (Prefusion)F protein (Prefusion)Prefusion F glycoproteinPre-F
02
Mechanism of action
Targeted by neutralizing antibodies to prevent virus-cell fusion and entry.
03
Biological functions
Virus-cell membrane fusionViral entryReceptor binding (heparan sulfate)Antigen presentation
04
Disease associations
Respiratory Syncytial Virus InfectionBronchiolitisPneumonia
05
Safety considerations
Potential for antibody-dependent enhancement (ADE) if vaccine-induced antibodies are non-neutralizing or sub-neutralizing.
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