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Target intelligence / Profile preview
Fusobacterium nucleatum (F. nucleatum)
- Target
- F. nucleatum
- Molecular classification
- Bacterium, Fusobacterium
01
Overview
Fusobacterium nucleatum is a Gram-negative, strictly anaerobic bacterium that is a common commensal in the human oral cavity and gastrointestinal tract. It plays a significant role in dental plaque formation and can become an opportunistic pathogen associated with numerous local and systemic diseases, including colorectal cancer and adverse pregnancy outcomes.
02
Biological functions
Biofilm formationInterspecies bacterial interactionsImmune modulationAdhesionInvasion
03
Disease associations
Periodontal diseasePeri-implantitisChorioamnionitisPreterm birthColorectal cancerInflammatory bowel diseaseCardiovascular diseaseRheumatoid arthritisRespiratory tract infectionsAlzheimer’s disease
04
Safety considerations
Opportunistic pathogenPotential for systemic dissemination
05
Biomarkers
FadA (potential diagnostic marker)
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