FXYD domain-containing ion transport regulator 5 (FXYD5)

FXYD domain-containing ion transport regulator 5 (FXYD5, also known as dysadherin) is a unique single-pass transmembrane glycoprotein in the FXYD protein family, which modulates the activity of the Na,K-ATPase by altering its kinetic properties, mainly increasing the maximal pump velocity and changing ion affinities[1][3][7]. Characterized by an extended, heavily glycosylated extracellular domain, FXYD5 not only regulates ion homeostasis but also plays a key role in weakening cell-cell adhesion by downregulating E-cadherin, promoting cytoskeletal remodeling, and facilitating cancer cell migration, invasion, and metastasis[1][2][4][5]. Its overexpression is strongly associated with poor prognosis in multiple cancers, and it acts through both direct modulation of cellular junctions and the upregulation of pro-metastatic chemokine signaling (e.g., CCL2), making it both a potential therapeutic target and a prognostic biomarker[1][2][7][8].

Other names

DysadherinRIC (mouse)DYSADIWU1HSPC113OIT2PRO6241UNQ2561/PRO6241keratinocytes associated transmembrane protein 1KCT1FXYD domain-containing ion transport regulator 5gamma5 subunit of Na,K-ATPase

Antibody-drug conjugates: Target dysadherin-expressing tumor cells via antibody recognition, leading to delivery of cytotoxic agent (e.g., cardiac glycoside) specifically to these cells[4]