FYN binding protein 1 (FYB1)

FYN binding protein 1 (FYB1) is a multifunctional adapter protein expressed predominantly in immune cells such as T cells, NK cells, monocytes, and mast cells. It plays a central role in T-cell receptor signaling, linking FYN kinase activity with cytoskeletal reorganization, immune cell adhesion, cytokine production, and platelet activation. FYB1 features multiple protein interaction domains and functions as a scaffold in complexes regulating actin dynamics, integrin-mediated signaling, and immune cell activation. Dysregulation of FYB1 is implicated in immune deficiencies and platelet disorders, and its signaling may be altered by pathogenic bacteria or genetic mutations

Other names

FYB1FYBADAP (Adhesion and degranulation-promoting adapter protein)SLAP-130 (SLP-76-associated phosphoprotein)FYN-bindingFYB-120/130p120/130 (isoforms)B630013F22RIKPRO0823RGD1563421THC3

Drugs modulating FYB1 downstream effects would: - Alter T-cell activation through FYN/ADAP/SLP-76 axis - Regulate immune cell adhesion and migration by affecting integrin signaling - Influence cytokine production (e.g., IL-2 expression) - Modulate platelet activation and function