Target intelligence / Profile preview

Fyn kinase

Molecular classification: Non-receptor tyrosine-protein kinase, Src family kinase, Enzyme, Kinase

Overview

Fyn kinase is a non-receptor tyrosine kinase belonging to the Src family. It is involved in various cellular processes, including signal transduction, cell growth, survival, and neuronal functions. Dysregulation of Fyn kinase has been implicated in diseases such as cancer, neurodegenerative disorders, and immune disorders, making it a potential therapeutic target.

Other names: Tyrosine-protein kinase FynSrc-like kinase (SLK)

Mechanism of action

Fyn kinase phosphorylates tyrosine residues on target proteins, thereby modulating their activity and downstream signaling.

Biological functions

Signal transductionCell growthCell survivalCell differentiationCell motilitySynaptic transmissionMyelinationAxon guidanceOligodendrocyte formationNeuronal differentiationNeuronal plasticityT-cell activationOocyte maturationSperm acrosome reaction

Disease associations

Cancer progressionMetastasisNeurodegenerative diseaseAlzheimer's diseaseParkinson's diseaseMultiple sclerosisAmyotrophic Lateral Sclerosis (ALS)Autism spectrum disorderAcute kidney injuryCNS injuries

Safety considerations

Potential for off-target effects due to involvement in multiple signaling pathways.Dysregulation can contribute to neoplastic transformation.

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