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Target intelligence / Profile preview
FYVE, RhoGEF and PH domain-containing protein 6 (FGD6)
- Target
- FGD6
- Molecular classification
- Guanine nucleotide exchange factor (GEF), Actin cytoskeleton regulator, FYVE domain-containing protein
01
Overview
FGD6 is a protein that acts as a guanine nucleotide exchange factor, activating the small GTPase Cdc42 to regulate actin cytoskeleton dynamics, coordinate cell adhesion, polarity, and membrane recycling, particularly in osteoclasts during bone degradation. It contains FYVE and two PH domains, which mediate membrane localization through phosphoinositide binding. FGD6 has been implicated in cancer biology, with its upregulation in gastric cancer correlating with poor prognosis, and in inherited syndromes such as Aarskog syndrome. While its key cellular functions and disease associations are noted, FGD6 is not currently established as a therapeutic target, nor are there drugs known to interact directly with it.
- Other names
- FGD6KIAA1362ZFYVE24FLJ11183zinc finger FYVE domain-containing protein 24
02
Mechanism of action
None established; no known drugs directly target FGD6
03
Biological functions
Actin cytoskeleton organizationRegulation of cell shapeFilopodium assemblyCell adhesionCoordination of cell polarityEndosomal membrane recyclingActivation of Cdc42 small GTPase
04
Disease associations
Cancer (elevated expression associated with poor prognosis in gastric cancer)Polypoidal choroidal vasculopathy susceptibilityAarskog syndrome (gene association)
05
Biomarkers
Overexpression in gastric cancer tissues as a prognostic biomarker
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