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Target intelligence / Profile preview
FYVE and coiled-coil domain autophagy adaptor 1 (FYCO1)
- Target
- FYCO1
- Molecular classification
- Other (Rab7 adaptor protein with roles in autophagosome vesicle transport; not a classic receptor, enzyme, transporter, channel, or transcription factor)
01
Overview
FYVE and coiled-coil domain autophagy adaptor 1 (FYCO1) is a cytosolic Rab7 adaptor protein that mediates microtubule plus end-directed transport of autophagic vesicles by interacting with several key partners, including the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and kinesin KIF5. It contains a RUN domain, FYVE-type zinc finger domain, and GOLD domain. FYCO1 is essential for proper autophagosome movement and maturation, playing a central role in autophagy. Genetic mutations in FYCO1 cause autosomal recessive congenital cataracts and are associated with rare forms of muscle disease such as inclusion body myositis. Its dysfunction may also alter cell migration and invasion processes, hinting at a broader biological relevance.
- Other names
- FYVE and coiled-coil domain-containing protein 1ZFYVE7FLJ13335Zinc finger FYVE domain-containing protein 7CATC2CTRCT18RUFY3RUN and FYVE domain containing 3
02
Biological functions
Autophagy (autophagosome transport and maturation)Microtubule-dependent vesicle transportRegulation of cell migration and invasion
03
Disease associations
Congenital cataractInclusion body myositisPossibly involved in cancer cell invasion and migration (as indicated by impact on HeLa cells)
04
Biomarkers
Mutations in FYCO1 as biomarkers for congenital cataracts
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