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Target intelligence / Profile preview
G antigen 10 (GAGE10)
- Target
- GAGE10
- Molecular classification
- Other (Cancer/testis antigen, protein coding gene)
01
Overview
G antigen 10 (GAGE10) is a member of the GAGE family of genes, which encode cancer/testis antigens. These proteins are expressed in a wide variety of tumors but have highly restricted expression in normal tissues, primarily limited to germ cells. GAGE10 is considered an immunogenic protein, making it a potential target for cancer immunotherapy, particularly for identifying or targeting tumors with cancer/testis antigen profiles[1][10]. No well-characterized physiological function has been established, but its selective expression suggests utility as a tumor biomarker and possible therapeutic target for cancer immunotherapy strategies[1][10].
- Other names
- GAGE10G antigen 10GAGE-10OTTHUMG00000024136
02
Biological functions
Other (not well defined; associated with tumor antigenicity and possibly involved in immune response due to its expression profile)
03
Disease associations
Cancer
04
Safety considerations
Tumor-restricted expression limits off-target safety concernsimmune-based targeting could have on-target, off-tumor risk in rare germ cell contexts
05
Biomarkers
Overexpression is a biomarker of several tumor types
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