G antigen 12E (GAGE12E)

G antigen 12E (GAGE12E) is a small protein consisting of 117 amino acids and is a member of the GAGE family of cancer/testis antigens[1]. These proteins are typically not expressed in most normal adult tissues but can be found at high levels in various tumors, such as melanoma, lung, and other cancers[5]. GAGE proteins are considered promising immunotherapy targets due to their restricted expression and immunogenicity, although their precise cellular function remains unclear. GAGE12E may contribute to cancer cell survival or evasion of immune recognition, but definitive mechanistic roles have not been fully established. No drugs are known to directly target GAGE12E, but its tumor-restricted expression supports its use as a potential cancer biomarker or target for T cell-based therapies[5][1].

Other names

G antigen 12B/C/D/EGAGE12BGAGE-12BGAGE-12CGAGE-12DGAGE-12EOTTHUMG00000024146