Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
G antigen 13 (GAGE13)
- Target
- GAGE13
- Molecular classification
- Cancer/Testis Antigen
01
Overview
G antigen 13 (GAGE13) is a member of the GAGE gene family of cancer/testis antigens, characterized by restricted expression to germ cells of the testis and aberrant activation in a range of human tumors. It is used as a biomarker for cancer diagnosis, prognosis, and as an immunotherapeutic target, particularly in cancer vaccine and T-cell based therapies. Its biological function in normal tissues is not well understood, but in cancer, its presence may facilitate immune evasion or tumorigenicity. Current research prioritizes its value in immuno-oncology, with ongoing efforts to develop therapies that exploit its selective tumor expression.
- Other names
- GAGE-13GAGE13GAGE12AG antigen 12AGAGE-12AOTTHUMG00000024138
02
Mechanism of action
Target for T-cell recognition in cancer immunotherapy; not directly targetable with small molecules or classic biologics, but leveraged in vaccine and T-cell therapy strategies
03
Biological functions
Proposed roles in tumor immune evasionLimited normal expression (primarily testis)Generally unknown function in normal physiology
04
Disease associations
Cancer (notably expressed in various tumor types, especially melanoma, lung cancer, sarcoma, and others)
05
Safety considerations
On-target off-tumor effects possible in testis (infertility risk)Low to no expression in normal somatic tissues minimizes risks of broader immune toxicity
06
Interacting drugs
None currently approved
1 more in the full profile.
07
Biomarkers
GAGE13 expression (for several malignancies)GAGE13 expression (to identify patients who may be responsive to cancer/testis antigen–directed therapies)
Beyond the preview
Go deeper on G antigen 13 (GAGE13).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on G antigen 13 (GAGE13).