G antigen pseudogene

The G antigen pseudogene (ENSG00000250393) is annotated as a human pseudogene[1][3]. Pseudogenes are genomic sequences similar to normal genes but typically non-functional due to mutations or lack of regulatory elements[2]. ENSG00000250393 is expressed in testis and various other tissues, but there is no evidence that it encodes a protein or has a clinical or therapeutic role[3]. The related “G antigen” in transfusion medicine refers to an Rh antigen implicated in hemolytic disease and transfusion reactions, but this is a protein epitope, not a gene target, and does not describe the pseudogene ENSG00000250393[4]. The "G antigen pseudogene" is not an actionable drug target, receptor, enzyme, transporter, or therapeutic biomolecule. It is a pseudogene (part of the non-coding RNA family) and does not have known canonical protein expression or therapeutic functions[1][2][3]. Its designation as a target is likely based on confusion with the functional G antigen protein epitope found on red blood cells[4], but this functional protein is not encoded by ENSG00000250393. There is no evidence for interacting small molecules, drugs, or biomarker status.

Other names

AC093664.1