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Target intelligence / Profile preview
G-patch domain and KOW motifs-containing protein (GPKOW)
- Target
- GPKOW
- Molecular classification
- RNA-binding protein, Spliceosome component, Other
01
Overview
G-patch domain and KOW motifs-containing protein (GPKOW) is an RNA-binding protein involved in pre-mRNA splicing, specifically acting as a component of the minor spliceosome that facilitates splicing of U12-type introns in pre-mRNAs. It interacts with protein kinase A and protein kinase X and is associated with the spliceosome. Mutations in the GPKOW gene have been linked to disorders such as microhydranencephaly and adrenoleukodystrophy. GPKOW contains both a G-patch domain and two KOW motifs, structural elements that are often present in proteins mediating RNA interactions and catalytic steps in RNA processing[2][5][6].
- Other names
- GPKOWGPATC5GPATCH5T54Spp2Mos2G-patch domain-containing protein 5Protein MOS2 homologProtein T54G patch domain containing 5
02
Biological functions
pre-mRNA splicingRNA bindingMinor spliceosome functionU12-type intron splicing
03
Disease associations
Microhydranencephaly (X-linked)AdrenoleukodystrophyOther
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