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Target intelligence / Profile preview
G-protein Alpha Subunit (Gα)
- Target
- Gα
- Molecular classification
- G protein, GTPase, Signaling protein
01
Overview
The G-protein alpha subunit is a key component of heterotrimeric G proteins, acting as a molecular switch in GPCR signaling pathways. It binds and hydrolyzes GTP, regulating the activity of downstream effectors like adenylyl cyclase, phospholipases, and ion channels. Different isoforms exist with specialized roles, making them therapeutic targets for various diseases.
- Other names
- G protein alpha subunitGTP-binding protein alpha subunit
02
Mechanism of action
Modulation of GTP binding and hydrolysis, affecting downstream signaling pathways.
03
Biological functions
Signal transductionRegulation of adenylyl cyclase activityRegulation of phospholipase activityRegulation of ion channel activityRegulation of RhoGEF activity
04
Disease associations
CancerNeurological disordersCardiovascular diseaseEndocrine disordersInflammation
05
Safety considerations
Off-target effects due to promiscuity of G protein interactions.Potential for constitutive activation or inactivation of signaling pathways.
06
Interacting drugs
Cholera toxin
3 more in the full profile.
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