G protein-biased signaling at μ opioid receptor (None)

G protein-biased signaling at the μ opioid receptor (MOR) refers to the phenomenon where certain ligands preferentially activate G protein-mediated intracellular pathways over β-arrestin-mediated pathways after binding to MOR. This functional selectivity, also known as biased agonism, aims to retain analgesic efficacy while reducing adverse effects linked with β-arrestin pathway activation. However, recent evidence suggests many therapeutic and adverse effects may still be mediated through the G protein pathway itself; some drugs labeled as "biased" might simply have low intrinsic efficacy rather than true bias.

Other names

MOR G protein-biased signalingBiased agonism at mu opioid receptorμ opioid receptor biased signaling

Selective activation of Gi/o protein signaling pathway over β-arrestin pathway, leading to inhibition of adenylate cyclase and modulation of ion channels.