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Target intelligence / Profile preview
G Protein-Coupled Receptor 120 (GPR120)
- Target
- GPR120
- Molecular classification
- G protein-coupled receptor
01
Overview
GPR120 (G Protein-Coupled Receptor 120), also known as FFAR4, is a receptor for long-chain free fatty acids. It plays a crucial role in regulating lipid metabolism, glucose uptake, inflammation, and has been implicated in various diseases including cancer and metabolic disorders. However, the query combines GPR120 with other molecules (AMPK and HO-1), which are distinct targets involved in different pathways.
- Other names
- FFAR4Free Fatty Acid Receptor 4
02
Mechanism of action
Activation of GPR120 leads to signaling cascades involving Gq/11 proteins, AMPK activation, and NF-κB pathway modulation, which influence glucose uptake and inflammation.
03
Biological functions
Signal transductionLipid metabolismGlucose metabolismInflammation regulationCell proliferation
04
Disease associations
CancerInflammationMetabolic disorders (Type 2 Diabetes)Cardiovascular disease
05
Safety considerations
Potential for tumor promotion in certain cancersinfluence on tamoxifen resistance
06
Interacting drugs
GW9508
2 more in the full profile.
07
Biomarkers
GPR120 expression in cancer tissuesinflammatory markers
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