G protein-coupled receptor 137B (GPR137B)

G protein-coupled receptor 137B (GPR137B) is an integral membrane protein located in lysosomes that plays a crucial role in regulating the activity and localization of mTORC1, an important signaling complex for cellular growth and metabolism. GPR137B facilitates lysosomal localization and activation of Rag GTPases, thereby modulating mTORC1’s function within the lysosome and contributing to the regulation of lysosomal morphology and autophagy. The protein’s expression is upregulated during kidney development and it may be involved in distinct pathological states such as isolated growth hormone deficiency and neuronal ceroid lipofuscinosis. As of September 2025, GPR137B is recognized as a validated molecular target for research, especially in the context of cell growth and lysosomal signaling, but no approved drugs or clinical biomarkers are associated directly with it.

Other names

TM7SF1Integral membrane protein GPR137BTransmembrane 7 superfamily member 1 proteinTransmembrane 7 superfamily member 1 (upregulated in kidney)GPR137B

Not established for drug interactions; mechanistically, GPR137B regulates mTORC1 signaling via interaction with Rag GTPases and localization to lysosomes.